5-Methylisoxazole-4-carboxylic acid → 5-Methyl-isoxazole-4-carboxylic acid [5-(7-fluoro-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-4-methyl-pyridin-3-ylmethyl]-amide

Participants

Reaction Steps

In analogy to the procedure described for the preparation of example 219, 6-(5-aminomethyl-4-methyl-pyridin-3-yl)-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride (example 226) has been coupled with 5-methyl-isoxazole-4-carboxylic acid to give the title compound as an off-white solid. MS: 409.6 (M+H+).

Provenance & Evidence