3,5-Dimethylisoxazole-4-carboxylic acid → 3,5-Dimethyl-isoxazole-4-carboxylic acid {2-[5-(7-fluoro-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-yloxy]-ethyl}-amide

Participants

Reaction Steps

In analogy to the procedure described for the preparation of example 219, 6-[5-(2-amino-ethoxy)-pyridin-3-yl]-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride (example 238) has been coupled with 3,5-dimethyl-isoxazole-4-carboxylic acid to give the title compound as a colorless solid. MS: 439.4 (M+H+).

Provenance & Evidence