Diisopropylethylamine → HCID 89701563, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of crude tert-butyl (1-{4-[bromo(phenyl)acetyl]phenyl}cyclobutyl)carbamate [Int-1-A] (288 mg, 0.55 mmol, 1.0 eq), 5-ethyl-3-methoxypyrazin-2-amine (84.4 mg, 0.55 mmol, 1 eq.; see step 2) and diisopropylethylamine (0.110 mL, 0.61 mmol, 1.1 eq) in 3.9 mL butyronitrile was heated at 120° C. for 20 hours. The reaction mixture was concentrated in vacuo. The crude mixture was purified via MPLC (Isolera, 50 g Snap-cartridge, eluent:hexane→hexane/ethyl acetate 1/1) to deliver 128 mg (25%) of the title compound in approximately 50-60 purity (UPLC). The title compound observed this way was forwarded to the next step without further purification.

Provenance & Evidence