Ammonia → HCID 71612645, compound

Participants

Reaction Steps

A solution of methyl 2-[4-(1-aminocyclobutyl)phenyl]-8-methoxy-3-phenylimidazo-[1,2-a]pyrazine-6-carboxylate [Example 7] (65 mg, 0.09 mmol, 80% purity (UPLC area-%), 1.0 eq) in 1.73 mL ammonia (7 M solution in methanol, ˜100 eq) was heated to 130° C. for 2 h in a single mode microwave oven. The volatile components were removed by the use of a rotary evaporator. The solvent was using a rotary evaporator and the crude material was purified via MPLC (Biotage Isolera, 10 g Snap-cartridge; eluent: DCM→DCM/ethanol (8/2)) to deliver 22 mg (43%) of the title compound.

Provenance & Evidence