4-Methyl-5-nitro-2,3'-bipyridine → 4-Methyl-6-(pyridin-3-yl)pyridin-3-amine

Participants

Reaction Steps

A mixture of 4-methyl-5-nitro-2,3′-bipyridine (215 g, 1 mol), Pd/C (10 g, 10%) and MeOH (1000 mL) was stirred at room temperature for 16 h under 10 atm of hydrogen. After reaction, the mixture was filtered. The filtrate was evaporated at reduced pressure to afford 4-methyl-2,3′-bipyridin-5-amine as a yellow solid (152 g, 82%)

Provenance & Evidence