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HRID1774984

反应详情

EQUATION

反应方程式

HRID 1774984 的结构方程式

REACTANTS

反应物

3
结构：CC1(C)OB(c2cccnc2)OC1(C)C
HCID2734656

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

C11H16BNO2

结构：CC1(C)OB(c2cnn(Cc3ccccc3)c2)OC1(C)C
HCID2734771

1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

C16H21BN2O2

结构：Brc1cc2c(I)nn(C3CCCCO3)c2cn1
HCID72698482

未命名化合物

PRODUCTS

生成物

1
结构：c1ccc(Cn2cc(-c3nn(C4CCCCO4)c4cnc(-c5cccnc5)cc34)cn2)cc1
HCID71253672

未命名化合物

收率 54%

PROCEDURE

实验过程

Following the Suzuki coupling procedure of Example 159, 5-bromo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine and 1-benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole were reacted and the product was consequently reacted by the Suzuki coupling procedure of Example 10 with 3-pyridineboronic acid pinacol ester. The product was purified via silica gel chromatography using a gradient of methanol in DCM to afford 236 mg (54%) of 3-(1-Benzyl-1H-pyrazol-4-yl)-5-(pyridin-3-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine over two steps. ESI MS m/z 437.1 (M+1).

WORKUP

后处理

  1. customwere reacted
  2. customThe product was purified via silica gel chromatography