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HRID1774990

反应详情

EQUATION

反应方程式

HRID 1774990 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OB(C2=COCCC2)OC1(C)C
HCID53217152

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-pyran

C11H19BO3

结构：Fc1cccc(-c2nn(C3CCCCO3)c3cnc(Br)cc23)n1
HCID86676681

未命名化合物

PRODUCTS

生成物

1
结构：Fc1cccc(-c2nn(C3CCCCO3)c3cnc(C4=COCCC4)cc23)n1
HCID71253776

未命名化合物

收率 45%

PROCEDURE

实验过程

Following the Suzuki coupling procedure of Example 10, 5-bromo-3-(6-fluoropyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine and 2-(3,4-dihydro-2H-pyran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane were reacted and purified via silica gel chromatography using a gradient of EtOAc in heptane to afford 68 mg (45%) of 5-(3,4-Dihydro-2H-pyran-5-yl)-3-(6-fluoropyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine. ESI MS m/z 381.1 (M+1).

WORKUP

后处理

  1. customwere reacted
  2. custompurified via silica gel chromatography