HRID1775004

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1

HCID16218385

Ethyl [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate

C13H21BN2O4

结构：Fc1cccc(-c2nn(C3CCCCO3)c3cnc(Br)cc23)n1

HCID86676681

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)Cn1cc(-c2cc3c(-c4cccc(F)n4)nn(C4CCCCO4)c3cn2)cn1

HCID71253737

未命名化合物

收率 56%

PROCEDURE

实验过程

Following the Suzuki coupling procedure of Example 10, 5-bromo-3-(6-fluoropyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine and ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate, were reacted and purified via silica gel chromatography using a gradient of EtOAc in heptane to afford 100 mg (56%) of Ethyl 2-(4-(3-(6-fluoropyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)-1H-pyrazol-1-yl)acetate. ESI MS m/z 451.1 (M+1).

WORKUP

后处理

customwere reacted
custompurified via silica gel chromatography