HCID 58464775, compound → HCID 71261626, compound

HRID 1775039Notes

Reaction equation

HRID 1775039 reaction equation
[NH:1]1[CH2:7][CH2:6][CH2:5][C@H:4]([NH:8][C:9](=[O:18])[O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:3][CH2:2]1.F[C:20]1[N:25]=[C:24]([C:26]2[C:34]3[C:29](=[CH:30][N:31]=[C:32]([C:35]4[CH:36]=[N:37][N:38]([CH3:40])[CH:39]=4)[CH:33]=3)[N:28]([CH:41]3[CH2:46][CH2:45][CH2:44][CH2:43][O:42]3)[N:27]=2)[CH:23]=[CH:22][CH:21]=1>>[CH3:40][N:38]1[CH:39]=[C:35]([C:32]2[CH:33]=[C:34]3[C:26]([C:24]4[N:25]=[C:20]([N:1]5[CH2:7][CH2:6][CH2:5][C@H:4]([NH:8][C:9](=[O:18])[O:10][CH2:11][C:12]6[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=6)[CH2:3][CH2:2]5)[CH:21]=[CH:22][CH:23]=4)=[N:27][N:28]([CH:41]4[CH2:46][CH2:45][CH2:44][CH2:43][O:42]4)[C:29]3=[CH:30][N:31]=2)[CH:36]=[N:37]1

Participants

3

Reactant 2

HCID 58464775HCID 58464775, compoundHCID 712534393-(6-fluoropyridin-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine

Product 1

HCID 71261626HCID 71261626, compoundYield 73.4%

Procedure

Following the procedure of Example 189, (S)-benzyl azepan-4-ylcarbamate and 3-(6-fluoropyridin-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine were reacted to give benzyl (4S)-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)azepan-4-ylcarbamate as a solid (73.4%). LC/MS: m/z 607.3 [M+1].

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-0c8dbe63861e4ab1bd77c0926e111b80
Source dataset
uspto-grants-2016_02
Patent number
US09260425B2

Reaction notes

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