HRID1775083

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1045

Putrescine

C4H12N2

结构：C[Si](C)(C)CCOCn1nc(-c2cccc(F)n2)c2cc(-c3cccnc3)ncc21

HCID71254057

3-(6-Fluoro-2-pyridinyl)-5-(3-pyridinyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazolo[3,4-c]pyridine

C22H24FN5OSi

PRODUCTS

生成物

结构：NCCCCNc1cccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)n1

HCID71254193

未命名化合物

收率 28%

PROCEDURE

实验过程

Following the procedures Example 271, 3-(6-fluoropyridin-2-yl)-5-(pyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridine and butane-1,4-diamine were reacted and the product was deprotected to give 283 as a yellow solid (20 mg, 28%) over two steps. 1H NMR (400 MHz, DMSO) δ 9.19-9.21 (m, 1H), 9.12-9.13 (m, 2H), 8.53-8.60 (m, 2H), 7.60-7.63 (m, 1H) 7.51-7.54 (m, 1H), 7.44-7.46 (m, 1H), 6.53 (d, J=6.4 Hz, 1H), 3.65 (t, J=1.2 Hz, 2H), 2.93 (t, J=1.2 Hz, 2H), 1.80-1.85 (m, 4H). ESI MS m/z=360 (M+1)

WORKUP

后处理

customwere reacted