Hydrochloric Acid → HCID 131734729, compound

Participants

Reaction Steps

A solution of 37% aqueous hydrogen chloride (240 mg, 2.36 mmol) was added to a solution of tofacitinib free base (0.7 g, 2.24 mmol) in acetone (10 mL). Stirring was continued at 23 to 25° C. for 23 hours and the resulting white suspension was filtered, washed with acetone (2×5 mL) and air-dried to yield 820 mg of tofacitinib hydrochloride as a white solid. 1H NMR analysis showed a molar ratio of tofacitinib hydrochloride to acetone of approximately 1:0.13 (2.1 wt %). A PXRD taken of this sample is shown in FIG. 12.

Provenance & Evidence