反应详情

5-Bromo-7H-pyrrolo[2,3-d]pyrimidine (7) is prepared by dissolving 7H-pyrrolo[2,3-d]pyrimidine (6) in chloroform and slowly adding Br2 in carbon tetrachloride at 0° C. After stirring for 1-2 hours, the reaction may be quenched in aqueous hydrochloric acid. Isolation by conventional means (e.g. extraction and silica gel chromatography) provides compound 7.

1. custom5-Bromo-7H-pyrrolo[2,3-d]pyrimidine (7) is prepared
2. customthe reaction
3. custommay be quenched in aqueous hydrochloric acid
4. extractionIsolation by conventional means (e.g. extraction and silica gel chromatography)