5-Iodo-7-(triisopropylsilyl)-7H-pyrrolo-[2,3-d]pyrimidine → (4-Chloro-benzyl)[5-(7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-pyridin-2-yl]-amine

HRID 1775162Notes

Reaction equation

HRID 1775162 reaction equation
C(OC(=O)[N:7]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=1)[C:8]1[CH:13]=[CH:12][C:11]([CH:14]=O)=[CH:10][N:9]=1)(C)(C)C.I[C:26]1[C:34]2[CH:33]=[N:32][CH:31]=[N:30][C:29]=2[N:28]([Si](C(C)C)(C(C)C)C(C)C)[CH:27]=1>>[Cl:23][C:20]1[CH:19]=[CH:18][C:17]([CH2:16][NH:7][C:8]2[CH:13]=[CH:12][C:11]([CH2:14][C:26]3[C:34]4[CH:33]=[N:32][CH:31]=[N:30][C:29]=4[NH:28][CH:27]=3)=[CH:10][N:9]=2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 509865195-Iodo-7-(triisopropylsilyl)-7H-pyrrolo-[2,3-d]pyrimidineHCID 59593313(4-Chloro-benzyl)-(5-formyl-pyridin-2-yl)-carbamic acid tert-butyl ester

Product 1

HCID 44470392(4-Chloro-benzyl)[5-(7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-pyridin-2-yl]-amine

Procedure

(4-Chloro-benzyl)-[5-(7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-pyridin-2-yl]-amine P-0001 was prepared in two steps from (4-chloro-benzyl)-(5-formyl-pyridin-2-yl)-carbamic acid tert-butyl ester 13 and 5-Iodo-7-triisopropylsilanyl-7H-pyrrolo[2,3-d]pyrimidine 38 as shown in Scheme 8.

Sources & evidence

ORD record
ord-919e1779ce1f476fbb65d595deea6412
Source dataset
uspto-grants-2016_02
Patent number
US09260437B2

Reaction notes

Loading…