2-Chloro-N,N-dimethylethylamine → HCID 89657246, compound

HRID 1775208Notes

Reaction equation

HRID 1775208 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:19](=[O:20])[NH:18][N:17]=[C:7]3[CH2:8][C:9]([CH3:16])([CH3:15])[CH2:10][C:11]4[NH:12][C:13]([CH:14]=1)=[C:5]2[C:6]=43.[CH3:21][N:22]([CH2:24][CH2:25]Cl)[CH3:23].CN(C)CCN1C2CC(C)(C)CC3=NNC(=O)C4C(C=23)=C1C=CC=4>>[CH3:21][N:22]([CH3:23])[CH2:24][CH2:25][N:12]1[C:11]2[CH2:10][C:9]([CH3:16])([CH3:15])[CH2:8][C:7]3=[N:17][NH:18][C:19](=[O:20])[C:4]4[C:5]([C:6]=23)=[C:13]1[CH:14]=[C:2]([F:1])[CH:3]=4

Participants

4

Reactant 3

HCID 79012-Chloro-N,N-dimethylethylamineHCID 71626462HCID 71626462, compoundHCID 136242898HCID 136242898, compound

Product 1

HCID 89657246HCID 89657246, compound

Procedure

Compound 40 was prepared from 8-fluoro-2,2-dimethyl-2,3,5,10-tetrahydro-[1,2]diazepino[3,4,5,6-def]carbazol-6(1H)-one and N,N-dimethylamino-2-chloroethane according to the procedures similar to those for Compound 28. 1H NMR (DMSO-d6) δ 10.1 (s, 1H), 7.56 (dd, 1H, J=9.6, 1.8 Hz), 7.21 (dd, 1H, J=10.2, 1.8 Hz), 4.22 (m, 2H), 2.74 (s, 2H), 2.51 (m, 2H), 2.26 (s, 2H), 2.17 (s, 6H), and 1.06 (s, 6H). MS (ESI) m/e [M+1]+ 343.

Sources & evidence

ORD record
ord-254f91aefef44da1a0179e7d5f0421d2
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

Loading…