Epichlorohydrin → HCID 71626594, compound

HRID 1775209Notes

Reaction equation

HRID 1775209 reaction equation
[CH3:1][C:2]1([CH3:19])[CH2:14][C:13]2=[N:15][NH:16][C:17](=[O:18])[C:10]3[C:11]4[C:12]2=[C:4]([NH:5][C:6]=4[CH:7]=[CH:8][CH:9]=3)[CH2:3]1.Cl[CH2:21][CH:22]1[CH2:24][O:23]1.CN(C)CCN1C2CC(C)(C)CC3=NNC(=O)C4C(C=23)=C1C=CC=4>>[CH3:1][C:2]1([CH3:19])[CH2:14][C:13]2=[N:15][NH:16][C:17](=[O:18])[C:10]3[C:11]4[C:12]2=[C:4]([N:5]([CH2:21][CH:22]2[CH2:24][O:23]2)[C:6]=4[CH:7]=[CH:8][CH:9]=3)[CH2:3]1

Participants

4

Reactant 3

HCID 7835EpichlorohydrinHCID 71626462HCID 71626462, compoundHCID 136242904HCID 136242904, compound

Product 1

HCID 71626594HCID 71626594, compound

Procedure

Compound 41 was prepared from 2,2-dimethyl-2,3,5,10-tetrahydro-[1,2]diazepino[3,4,5,6-def]carbazol-6(1H)-one and 2-(chloromethyl)oxirane according to the procedures similar to those for Compound 28. 1H NMR (DMSO-d6) δ 9.96 (s, 1H), 7.65 (d, 1H, J=8.4 Hz), 7.49 (d, 1H, J=7.8 Hz), 7.18 (dd, 1H, J=8.4, 7.8 Hz), 4.60-4.63 (m, 1H), 4.21-4.24 (m, 1H), 3.27-3.29 (m, 1H), 2.76-2.77 (m, 1H), 2.75 (s, 2H), 2.46-2.48 (m, 1H), 2.26 (s, 2H), and 0.92 (s, 6H). MS (ESI) m/e [M+1]+ 310.

Sources & evidence

ORD record
ord-685b232177cb4a86ad9ce114506213d3
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

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