Acetone → HCID 136242915, compound

HRID 1775213Notes

Reaction equation

HRID 1775213 reaction equation
O=[C:2]1[C:14]2[C:13]3[C:12]([C:15]([O:17]C)=O)=[CH:11][CH:10]=[CH:9][C:8]=3[NH:7][C:6]=2[CH2:5][NH:4][CH2:3]1.CN1CC2NC3C=CC=C4C(=O)[NH:34][N:35]=C(C=2C=34)C1.[CH3:37][C:38]([CH3:40])=O>>[CH:38]([N:4]1[CH2:5][C:6]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[C:12]4[C:15](=[O:17])[NH:34][N:35]=[C:2]([C:14]=2[C:13]=34)[CH2:3]1)([CH3:40])[CH3:37]

Participants

4

Reactant 3

HCID 180AcetoneHCID 89657350HCID 89657350, compoundHCID 136242914HCID 136242914, compound

Product 1

HCID 136242915HCID 136242915, compound

Procedure

Compound 45 was prepared from methyl 4-oxo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-5-carboxylate and acetone according to the procedures similar to those for Compound 44. 1H NMR (DMSO-d6) δ 11.7 (s, 1H), 9.83 (s, 1H), 7.43 (d, 1H, J=8.4 Hz), 7.38 (d, 1H, J=7.6 Hz), 7.08 (dd, 1H, J=8.4, 7.6 Hz), 3.78 (s, 2H), 3.26 (s, 2H), 2.93-2.96 (m, 1H), 1.04 (d, 6H, J=6.4 Hz). MS (ESI) m/e [M+1]+ 269.

Sources & evidence

ORD record
ord-a73112474d84435e98085c6c146fb949
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

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