Acetone → HCID 136242916, compound

HRID 1775214Notes

Reaction equation

HRID 1775214 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:16]([O:18]C)=O)[C:5]2[C:6]3[C:14](=O)[CH2:13][NH:12][CH2:11][C:7]=3[NH:8][C:9]=2[CH:10]=1.CN1CC2NC3C=CC=C4C(=O)[NH:35][N:36]=C(C=2C=34)C1.[CH3:38][C:39]([CH3:41])=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:16](=[O:18])[NH:35][N:36]=[C:14]3[C:6]4[C:5]2=[C:9]([NH:8][C:7]=4[CH2:11][N:12]([CH:39]([CH3:41])[CH3:38])[CH2:13]3)[CH:10]=1

Participants

4

Reactant 3

HCID 180AcetoneHCID 89657628HCID 89657628, compoundHCID 136242914HCID 136242914, compound

Product 1

HCID 136242916HCID 136242916, compound

Procedure

Compound 46 was prepared from methyl 7-fluoro-4-oxo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-5-carboxylate and acetone according to the procedures similar to those for Compound 44. 1H NMR (DMSO-d6) δ 11.8 (s, 1H), 10.1 (s, 1H), 7.35 (dd, 1H, J=2.4, 9.6 Hz), 7.18 (dd, 1H, J=2.4, 10.2 Hz), 3.82 (s, 2H), 3.32 (s, 2H), 2.98-3.00 (m, 1H), 1.09 (d, 6H, J=7.2 Hz). MS (ESI) m/e [M+1]+ 287.

Sources & evidence

ORD record
ord-75698f67667643aea958fef0dfe1f906
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

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