2-Chloro-N,N-dimethylethylamine → HCID 71626666, compound

HRID 1775216Notes

Reaction equation

HRID 1775216 reaction equation
[CH:1]1([C:4]([N:6]2[CH2:18][C:17]3[NH:16][C:15]4[CH:14]=[CH:13][CH:12]=[C:11]5[C:19](=[O:22])[NH:20][N:21]=[C:8]([C:9]=3[C:10]=45)[CH2:7]2)=[O:5])[CH2:3][CH2:2]1.[CH3:23][N:24]([CH2:26][CH2:27]Cl)[CH3:25].CN(C)CCN1C2CC(C)(C)CC3=NNC(=O)C4C(C=23)=C1C=CC=4>>[CH:1]1([C:4]([N:6]2[CH2:18][C:17]3[N:16]([CH2:27][CH2:26][N:24]([CH3:25])[CH3:23])[C:15]4[CH:14]=[CH:13][CH:12]=[C:11]5[C:19](=[O:22])[NH:20][N:21]=[C:8]([C:9]=3[C:10]=45)[CH2:7]2)=[O:5])[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 79012-Chloro-N,N-dimethylethylamineHCID 71626462HCID 71626462, compoundHCID 136242917HCID 136242917, compound

Product 1

HCID 71626666HCID 71626666, compound

Procedure

Compound 48 was prepared from 2-(cyclopropanecarbonyl)-2,3,4,9-tetrahydro-2,4, 9,10-tetraazacyclohepta[def]fluoren-8(1H)-one and N,N-dimethylamino-2-chloroethane according to the procedures similar to those for Compound 28. 1H NMR (DMSO-d6) δ 10.0 (s, 1H), 7.67 (d, 1H, J=8.4 Hz), 7.51 (d, 1H, J=7.8 Hz), 7.23 (dd, 1H, J=8.4, 7.8 Hz), 5.22 (s, 1H), 4.98 (s, 1H), 4.55 (s, 1H), 4.28-4.35 (m, 3H), 2.58-2.62 (m, 2H), 2.19 (s, 6H), 2.09-2.13 (m, 1H), and 0.79 (s, 4H). MS (ESI) m/e [M+1]+ 366.

Sources & evidence

ORD record
ord-608118d47aa4446bb2e1db25b65fb3c3
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

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