3,3-Dimethylbutanal → HCID 136242922, compound

HRID 1775221Notes

Reaction equation

HRID 1775221 reaction equation
[CH2:1]1[NH:13][CH2:12][C:11]2[NH:10][C:9]3[CH:8]=[CH:7][CH:6]=[C:5]4[C:14](=[O:17])[NH:15][N:16]=[C:2]1[C:3]=2[C:4]=34.[CH3:18][C:19]([CH3:24])([CH3:23])[CH2:20][CH:21]=O.CN1CC2NC3C=CC=C4C(=O)NN=C(C=2C=34)C1>>[CH3:18][C:19]([CH3:24])([CH3:23])[CH2:20][CH2:21][N:13]1[CH2:12][C:11]2[NH:10][C:9]3[CH:8]=[CH:7][CH:6]=[C:5]4[C:14](=[O:17])[NH:15][N:16]=[C:2]([C:3]=2[C:4]=34)[CH2:1]1

Participants

4

Reactant 3

HCID 763353,3-DimethylbutanalHCID 136242912HCID 136242912, compoundHCID 136242914HCID 136242914, compound

Product 1

HCID 136242922HCID 136242922, compound

Procedure

Compound 54 was prepared from 2,3,4,9-tetrahydro-2,4,9,10-tetraazacyclohepta[def]fluoren-8(1H)-one and 3,3-dimethylbutanal according to the procedures similar to those for Compound 44. 1H NMR (DMSO-d6) δ 11.9 (s, 1H), 9.89 (s, 1H), 7.48 (d, 1H, J=7.8 Hz), 7.43 (d, 1H, J=7.2 Hz), 7.13 (dd, 1H, J=7.2, 7.8 Hz), 3.81 (br s, 2H), 3.29 (br s, 2H), 2.57-2.58 (m, 2H), 1.43-1.46 (m, 2H), and 0.91 (s, 9H). MS (ESI) m/e [M+1]+ 311.

Sources & evidence

ORD record
ord-b438364db3f040b6b094281fc7a6d2fc
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

Loading…