HCID 136242912, compound → HCID 136242930, compound

HRID 1775232Notes

Reaction equation

HRID 1775232 reaction equation
C(OC(=O)[NH:10][C:11]([CH3:32])([CH3:31])[C:12](=[O:30])[N:13]1[CH2:25][C:24]2[NH:23][C:22]3[CH:21]=[CH:20][CH:19]=[C:18]4[C:26](=[O:29])[NH:27][N:28]=[C:15]([C:16]=2[C:17]=34)[CH2:14]1)C1C=CC=CC=1.C1NCC2NC3C=CC=C4C(=O)NN=C1C=2C=34>[Pd]>[NH2:10][C:11]([CH3:32])([CH3:31])[C:12]([N:13]1[CH2:25][C:24]2[NH:23][C:22]3[CH:21]=[CH:20][CH:19]=[C:18]4[C:26](=[O:29])[NH:27][N:28]=[C:15]([C:16]=2[C:17]=34)[CH2:14]1)=[O:30]

Participants

4

Reactant 2

HCID 136242912HCID 136242912, compoundHCID 136952096HCID 136952096, compound

Product 1

HCID 136242930HCID 136242930, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Compound 62 was prepared from benzyl(2-methyl-1-oxo-1-(8-oxo-8,9-dihydro-2,4,9,10-tetraazacyclohepta[def]fluoren-2(1H,3H,4H)-yl)propan-2-yl)carbamate and Pd/C (10%) according to the procedure similar to that for Compound 42. 1H NMR (DMSO-d6) δ 11.8 (s, 1H), 9.99 (s, 1H), 7.48 (d, 1H, J=8.0 Hz), 7.43 (d, 1H, J=7.2 Hz), 7.13 (dd, 1H, J=8.0, 7.2 Hz), 5.29-5.31 (m, 2H), 4.69-4.75 (m, 2H), 1.26 (s, 6H). MS (ESI) m/e [M+1]312.

Sources & evidence

ORD record
ord-15525312a8224f73ac377a56352bf769
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

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