関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Amino-4-(trifluoromethyl)benzamide | HCID 69739 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 2-(Ethylsulfanyl)benzaldehyde | HCID 13082726 | — |
| 反応物 | Sodium Bisulfite | HCID 23665763 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | 2-(2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one | HCID 136968753 | 87% |
反応手順
A mixture of 1.0 g of 2-amino-4-trifluromethylbenzamide, 813 mg of 2-ethylsulfanylbenzaldehyde, 764 mg of sodium bisulfite and 4 ml of DMA was stirred at 150° C. for 8 hours. A saturated aqueous sodium bicarbonate solution and water were added to the cooled reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 1.49 g of 2-(2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09260436B2 |
|---|
| 出典データセット | uspto-grants-2016_02 |
|---|
| ORD ID | ord-6cbdb97a48e549beb3af7e9e6d4be56b |
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| 出典メモ | uspto-grants-2016_02 |
|---|
