Phosphorus oxybromide → 4-Bromo-2-(2-ethylsulfanylphenyl)-7-trifluoromethylquinazoline

Participants

Reaction Steps

A mixture of 500 mg of 2-(2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one, 615 mg of phosphorus oxybromide and 2 ml of acetonitrile was refluxed for 4 hours. A saturated aqueous sodium bicarbonate solution was added to the cooled reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 149 mg of 4-bromo-2-(2-ethylsulfanylphenyl)-7-trifluoromethylquinazoline (Compound of Present Invention 3).

Provenance & Evidence