HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1775266Generated: October 26, 2026
2-Amino-4-(trifluoromethyl)benzamide → 2-(4-chloro-2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one
https://huagongshe.com/reaction/1775266
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Amino-4-(trifluoromethyl)benzamide | HCID 69739 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Reactant | 4-Chloro-2-ethylsulfanylbenzaldehyde | HCID 114863540 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 2-(4-chloro-2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one | HCID 136968750 | 80.7% |
Reaction Steps
A mixture of 1.0 g of 2-amino-4-trifluromethylbenzamide, 944 mg of 4-chloro-2-ethylsulfanylbenzaldehyde, 765 mg of sodium bisulfite and 4 ml of DMA was stirred at 150° C. for 15 hours. A saturated aqueous sodium bicarbonate solution and water were added to the cooled reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 1.46 g of 2-(4-chloro-2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09260436B2 |
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| Source dataset | uspto-grants-2016_02 |
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| ORD ID | ord-f5e32b9844ec419e83db4936c186d6bb |
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| Source note | uspto-grants-2016_02 |
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