HCID 118035057, compound → HCID 91667369, compound

HRID 1775293Notes

Reaction equation

HRID 1775293 reaction equation
Br.[Br:2][C:3]1[CH:4]=[N:5][C:6]2[N:7]([CH2:9][C:10]([C:13]([F:16])([F:15])[F:14])(O)[N:11]=2)[CH:8]=1>C(O)C>[Br:2][C:3]1[CH:4]=[N:5][C:6]2[N:7]([CH:9]=[C:10]([C:13]([F:16])([F:15])[F:14])[N:11]=2)[CH:8]=1

Participants

3

Reactant 1

HCID 118035057HCID 118035057, compound

Product 1

HCID 91667369HCID 91667369, compoundYield 76.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.97 g of resulting 6-bromo-2-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-2-ol hydrobromide and 10 ml of ethanol was stirred under heat-reflux for 5 hours. The cooled reaction mixture was concentrated under reduced pressure, then water was added, and the mixture was extracted with ethyl acetate. The resulting matter was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.54 g of 6-bromo-2-trifluoromethyl-imidazo[1,2-a]pyrimidine.

Workup

  1. temperatureunder heat-reflux for 5 hours
  2. customThe cooled reaction mixture
  3. concentrationwas concentrated under reduced pressure
  4. additionwater was added
  5. extractionthe mixture was extracted with ethyl acetate
  6. dry with materialThe resulting matter was dried over anhydrous sodium sulfate
  7. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-6d6c829d95e6494f995cea2d30fb9d15
Source dataset
uspto-grants-2016_02
Patent number
US09260436B2

Reaction notes

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