1,2-Dimethoxyethane → HCID 118034959, compound

HRID 1775295Notes

Reaction equation

HRID 1775295 reaction equation
[Br:1][CH2:2][C:3](=[O:8])[C:4]([F:7])([F:6])[F:5].[NH2:9][C:10]1N=[C:14]([Br:16])[CH:13]=[CH:12][N:11]=1.[CH3:17]OCCOC>>[BrH:1].[Br:16][C:14]1[CH:13]=[CH:12][N:11]2[CH2:2][C:3]([C:4]([F:7])([F:6])[F:5])([OH:8])[N:9]=[C:10]2[CH:17]=1

Participants

4

Reactant 3

HCID 80711,2-Dimethoxyethane2×HCID 790083-Bromo-1,1,1-trifluoro-2-propanoneHCID 128034964-Bromopyrimidin-2-amine

Product 1

HCID 118034959HCID 118034959, compound

Procedure

A mixture of 1.14 g of 3-bromo-1,1,1-trifluoropropan-2-one and 10 ml of DME was added to a mixture of 1.04 g of 2-amino-4-bromopyrimidine and 10 ml of DME, and the mixture was stirred at room temperature for 1 day. The precipitated solid was taken by filtration, washed with 10 ml of DME, and dried to obtain 1.92 g of 7-bromo-2-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridin-2-ol hydrobromide.

Workup

  1. filtrationThe precipitated solid was taken by filtration
  2. washwashed with 10 ml of DME
  3. customdried

Sources & evidence

ORD record
ord-bedc6cc4a85546d9b9738cab5f9d3a96
Source dataset
uspto-grants-2016_02
Patent number
US09260436B2

Reaction notes

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