5-Bromo-2,4-dichloropyrimidine → benzyl N-[1-[[(5-bromo-2-chloro-pyrimidin-4-yl)amino]methyl]propyl]carbamate

Participants

Role	Name	HCID	Charge
Reactant	5-Bromo-2,4-dichloropyrimidine	HCID 289973	—
Reactant	2-N-Cbz-butane-1,2-diamine	HCID 45072685	—
Reactant	tert-butyl N-[2-[(5-bromo-2-chloro-pyrimidin-4-yl)amino]ethyl]carbamate	HCID 86695590	—
Product	benzyl N-[1-[[(5-bromo-2-chloro-pyrimidin-4-yl)amino]methyl]propyl]carbamate	HCID 89825160	—

Reaction Steps

benzyl N-[1-[[(5-bromo-2-chloro-pyrimidin-4-yl)amino]methyl]propyl]carbamate is synthesized by treating 5-Bromo-2,4-dichloropyrimidine with benzyl N-[1-(aminomethyl)propyl]carbamate using similar experimental conditions as described for the synthesis of tert-butyl N-[2-[(5-bromo-2-chloro-pyrimidin-4-yl)amino]ethyl]carbamate. LCMS (ESI) (M+H) 413

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09260442B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-471c191ae4254fd59fecf3c296115a0f
Source note	uspto-grants-2016_02