HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2,4-dichloropyrimidine → tert-butyl N-[1-[[(5-bromo-2-chloro-pyrimidin-4-yl)amino]methyl]cyclopentyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2,4-dichloropyrimidine | HCID 289973 | — |
| Reactant | tert-butyl N-[1-(aminomethyl)cyclopentyl]carbamate | HCID 16740809 | — |
| Reactant | tert-butyl N-[2-[(5-bromo-2-chloro-pyrimidin-4-yl)amino]ethyl]carbamate | HCID 86695590 | — |
| Product | tert-butyl N-[1-[[(5-bromo-2-chloro-pyrimidin-4-yl)amino]methyl]cyclopentyl]carbamate | HCID 89825179 | — |
Reaction Steps
tert-butyl N-[1-[[(5-bromo-2-chloro-pyrimidin-4-yl)amino]methyl]cyclopentyl]carbamate was synthesized by treating 5-bromo-2,4-dichloropyrimidine with tert-butyl N-[1-(aminomethyl)cyclopentyl]carbamate using similar experimental conditions as described for the synthesis of tert-butyl N-[2-[(5-bromo-2-chloro-pyrimidin-4-yl)amino]ethyl]carbamate. LCMS (ESI) 405 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260442B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-9ed5bc99649648b9a9089a47a446509f |
| Source note | uspto-grants-2016_02 |