Hydrochloric Acid → (E)-4,4-Difluoropent-2-enoic acid

Participants

Reaction Steps

The product of step C was dissolved in ethanol (24 ml), 4M NaOH was added (12 ml) and the mixture was stirred at room temperature for two hours. The mixture was acidified with 1M HCl and extracted with ethyl acetate. The organic extract was dried over magnesium sulfate, the solvent was removed under reduced pressure. 2.67 g of a colourless oil were obtained. MS (ESI) m/z=135.0 [M−1]−.

Provenance & Evidence