Hydrochloric Acid → 1-(4-Methylpyridin-2-YL)-1,4-diazepane dihydrochloride

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Reaction Steps

tert-Butyl 4-(4-methyl-2-pyridyl)-1,4-diazepane-1-carboxylate (91 mg, 0.312 mmol) was dissolved in DCM under nitrogen. Hydrochloric acid (4N in dioxane, 1.56 ml, 6.25 mmol) was added and the mixture was stirred at room temperature overnight. The mixture was evaporated under reduced pressure to give 84 mg of a solid (quantitative). MS (ESI) m/z=192.2 [M+1]+.

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