Hydrochloric Acid → 2-Methyl-3-(piperidin-4-yl)pyridine hydrochloride

Participants

Reaction Steps

tert-Butyl 4-(2-methyl-3-pyridyl)piperidine-1-carboxylate (100 mg, 0.36 mmol) was dissolved in methanol (4 ml) and combined with hydrochloric acid (4N in dioxane, 10 ml) and the mixture was stirred at room temperature for two hours. The volatiles were removed under reduced pressure to yield 54 mg of a beige solid (0.25 mmol, 69%) MS (ESI) m/z=177.1 [M+1]+.

Provenance & Evidence