Dichloromethane → HCID 89825932, compound

Participants

Reaction Steps

tert-Butyl 4-(6-fluoro-4-methyl-2-pyridyl)piperazine-1-carboxylate (360 mg, 1.22 mmol) was dissolved in a mixture of DCM (20 ml) and trifluoroacetic acid (5 ml) and stirred at room temperature for 2 hours. The mixture was concentrated under reduced pressure, dissolved in THF, evaporated again and again dissolved in THF. Hydrochloric acid (4N in dioxan) was added, the precipitate was collected by filtration, washed with THF and dried under reduced pressure to give 265 mg of a solid (1.14 mmol, yield 93%) MS (multi-mode) m/z=196.1 [M+1]+.

Provenance & Evidence