Cesium fluoride → {(3R)-4-[4-(2-aminopyrimidin-5-yl)-7-(3,3-difluorocyclobutyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl]morpholin-3-yl}methanol

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-[7-(3,3-difluorocyclobutyl)-2-(methylsulfinyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine (35 mg, 0.096 mmol) in acetonitrile (0.3 mL) was added (3R)-morpholin-3-ylmethanol (68 mg, 0.576 mmol) and CsF (56 mg, 0.288 mmol), and the reaction mixture was sealed and heated at 120° C. for 96 h.

Provenance & Evidence