Hydrochloric Acid → HCID 118436287, compound

Participants

Reaction Steps

To a flask containing tert-butyl(3S)-3-{4-(2-aminopyrimidin-5-yl)-2-[(3S)-3-methylmorpholin-4-yl]-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-3-methylpyrrolidine-1-carboxylate (3290 mg, 6.625 mmol) in 31 mL MeOH was added 4 N HCl in dioxane (33 mL, 132 mmol) dropwise at 0° C. and the mixture was stirred at room temperature for 2 h. The mixture was diluted with toluene and concentrated. Additional toluene was added and the solution was concentrated to give the title compound (3.73 g, >99%) as a yellow foam. 1H NMR (400 MHz, DMSO-d6) δ 9.62 (br s, 2 H), 8.69 (s, 2 H), 7.33-7.11 (m, 2H), 4.63-4.52 (m, 1 H), 4.20 (d, J=11.5 Hz, 1 H), 4.03-3.89 (m, 2 H), 3.83-3.18 (m, 10 H), 3.14-3.03 (m, 2 H), 2.71-2.55 (m, 1 H), 2.20-2.04 (m, 1 H), 1.48 (s, 3 H), 1.28 (d, J=6.7 Hz, 3 H). m/z (APCI+) for C20H28N8O 397.5 (M+H)+.

Provenance & Evidence