Hydrochloric Acid → HCID 118436150, compound

Participants

Reaction Steps

A solution of 4 M hydrochloric acid in dioxane (5 mL) was added to a solution of the product of Example 4, step 2, tert-butyl(3S)-3-[4-chloro-2-(morpholin-4-yl)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-3-methylpyrrolidine-1-carboxylate (424 mg, 1.00 mmol) in DCM (5 mL) at room temperature, and the mixture was stirred for 20 h. The reaction mixture was concentrated to give 4-chloro-7-[(3S)-3-methylpyrrolidin-3-yl]-2-(morpholin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine hydrochloride (550 mg). This material was dissolved in a biphasic mixture of DCM (10 mL) and saturated aqueous

Provenance & Evidence