1-Ethynyl-4-methoxybenzene → 4-chloro-3-(3-methoxyphenyl)-5-(4-methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-c]pyridazine

Participants

Role	Name	HCID	Charge
Reactant	1-Ethynyl-4-methoxybenzene	HCID 251020	—
Reactant	3-(3-Methoxyphenyl)-3-oxopropanenitrile	HCID 584716	—
Reactant	4-chloro-3-(2-chlorophenyl)-1-methyl-5-phenyl-1H-pyrazolo[3,4-c]pyridazine	HCID 66576482	—
Product	4-chloro-3-(3-methoxyphenyl)-5-(4-methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-c]pyridazine	HCID 66576559	—

Reaction Steps

Compound 15 was synthesised following similar procedures outlined in Example 1 (Compound 37), using 3-methoxybenzoylacetonitrile instead of 2-chlorobenzoyl acetonitrile in Step 1 and 4-methoxyphenyl acetylene instead of phenyl acetylene in Step 4.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09260381B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-88872bb8d26744839a24fc5c3d72d8b0
Source note	uspto-grants-2016_02