p-Ethynyltoluene → HCID 66576725, compound

HRID 1775523Notes

Reaction equation

HRID 1775523 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[N:14]([CH3:24])[N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3Cl)[C:3]=12.[CH3:25]N1C(N)=CC(C2C=CC=CC=2)=N1.C1(C)C=CC(C#C)=CC=1>>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([CH3:25])=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[N:14]([CH3:24])[N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:3]=12

Participants

4

Reactant 3

HCID 13018p-EthynyltolueneHCID 5177791-Methyl-3-phenyl-1H-pyrazol-5-amineHCID 665764824-chloro-3-(2-chlorophenyl)-1-methyl-5-phenyl-1H-pyrazolo[3,4-c]pyridazine

Product 1

HCID 66576725HCID 66576725, compound

Procedure

Compound 11 was synthesised following similar procedures outlined in Example 1 (Compound 37), starting from Step 2 using 1-methyl-3-phenyl-1H-pyrazol-5-amine instead of 3-(2-chlorophenyl)-1-methyl-1H-pyrazol-5-amine and 4-tolylacetylene instead of phenyl acetylene in Step 4.

Sources & evidence

ORD record
ord-1e9f87a9c5fe4bbc80b72ff7ae42b77a
Source dataset
uspto-grants-2016_02
Patent number
US09260381B2

Reaction notes

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