4-(Trifluoromethyl)benzaldehyde → HCID 66576888, compound

HRID 1775539Notes

Reaction equation

HRID 1775539 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[N:14]([CH3:24])[N:15]=[C:16]([C:17]3[CH:18]=[C:19](C)[CH:20]=[CH:21][CH:22]=3)[C:3]=12.[F:25][C:26]([F:36])([F:35])C1C=CC(C=O)=CC=1>>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[N:14]([CH3:24])[N:15]=[C:16]([C:17]3[CH:18]=[CH:19][C:20]([C:26]([F:36])([F:35])[F:25])=[CH:21][CH:22]=3)[C:3]=12

Participants

3

Reactant 2

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 66576808HCID 66576808, compound

Product 1

HCID 66576888HCID 66576888, compound

Procedure

Compound 23 was synthesised following similar procedures outlined in Example 24 (Compound 19), using 4-trifluoromethylbenzaldehyde instead of 3-methylbenzaldehyde in Step 1. As a slightly modified procedure, in Step 2, the reaction mixture was filtered and following evaporation of the filtrate, purification of (3,5-dichloro-6-phenylpyridazin-4-yl)(4-(trifluoromethyl)phenyl)methanone was carried out by trituration of the solid residue in diethyl ether.

Workup

  1. filtrationAs a slightly modified procedure, in Step 2, the reaction mixture was filtered
  2. customevaporation of the filtrate, purification of (3,5-dichloro-6-phenylpyridazin-4-yl)(4-(trifluoromethyl)phenyl)methanone

Sources & evidence

ORD record
ord-eaa952510605446296637087f4647999
Source dataset
uspto-grants-2016_02
Patent number
US09260381B2

Reaction notes

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