Cyclohexane → HCID 66576409, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (0° C.) stirred solution of ethyl 2-(4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-1-yl)propanoate (72 mg, 0.177 mmol) in THF (0.5 mL) was added dropwise a 1.1 M solution of diisobutylaluminum hydride in cyclohexane (1 mL, 1.1 mmol). After 15 minutes, a saturated solution of ammonium chloride and CH2Cl2 were added at 0° C. to the reaction mixture. The aqueous phase was extracted with CH2Cl2 and the organic phases combined, dried over MgSO4, filtered and evaporated. Purification using preparative HPLC gave Compound 96 as an off-white solid (28 mg).

Provenance & Evidence