反应详情

In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (100 mg, 0.43 mmol), triethyl orthoformate (1.0 ml), 2-fluoroaniline (88.6 mg, 0.8 mmol), and acetic acid (0.12 ml) were used to give 36 mg (0.11 mmol, 26% yield) of the title compound.