HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyaniline → 3-(2-Methoxyphenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyaniline | HCID 7000 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Methyl 3-amino-4-phenylthiophene-2-carboxylate | HCID 2759782 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-(2-Methoxyphenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78320168 | 71% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (200 mg, 0.86 mmol), triethyl orthoformate (2 ml), o-anisidine (201 mg, 1.63 mmol), and acetic acid (0.2 ml) were used to give 204 mg (0.61 mmol, 71% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-e8a6146965ce45619f1f35c397decfee |
| Source note | uspto-grants-2016_02 |