HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenol → 3-(4-Hydroxyphenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Methyl 3-amino-4-phenylthiophene-2-carboxylate | HCID 2759782 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-(4-Hydroxyphenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78320173 | 41% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (500 mg, 2.14 mmol), triethyl orthoformate (5 ml), 4-aminophenol (444 mg, 4.07 mmol), and acetic acid (0.5 ml) were used to give 283 mg (0.88 mmol, 41% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-7c45f4413d7f4875bd409572554ddab2 |
| Source note | uspto-grants-2016_02 |