HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → HCID 78321120, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 3-Aminostyrene | HCID 4260041 | — |
| Reactant | 1325307-27-4 | HCID 53335886 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 78321120 | HCID 78321120 | 57.4% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(2-fluorophenyl)thiophene-2-carboxylate (80 mg, 0.3 mmol), triethyl orthoformate (0.79 ml), 3-vinylaniline (70.6 mg, 0.59 mmol), and acetic acid (0.09 ml) were used to give 64 mg (0.18 mmol, 57.4% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-bbcadd0d29ee43c5997c1406f5ba08b2 |
| Source note | uspto-grants-2016_02 |