HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroaniline → HCID 78321441, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Methyl 3-amino-4-(2-chlorophenyl)thiophene-2-carboxylate | HCID 53335888 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 78321441 | HCID 78321441 | 23% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(2-chlorophenyl)thiophene-2-carboxylate (100 mg, 0.373 mmol), triethyl orthoformate (2 ml), 4-chloroaniline (88.5 mg, 0.70 mmol), and acetic acid (0.1 ml) were used to give 31.3 mg (0.084 mmol, 23% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-8d177e2e11cb4eefbdf7e5c55cff13e1 |
| Source note | uspto-grants-2016_02 |