HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Anisidine → HCID 78321749, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 2-Thiophenecarboxylic acid, 3-amino-4-(3-chlorophenyl)-, methyl ester | HCID 53335889 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 78321749 | HCID 78321749 | 76% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(3-chlorophenyl)thiophene-2-carboxylate (80 mg, 0.3 mmol), triethyl orthoformate (0.66 ml), p-anisidine (68.5 mg, 0.56 mmol), and acetic acid (0.09 ml) were used to give 84 mg (0.23 mmol, 76% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-65102f8d96bf438db2a2121dddaca0ff |
| Source note | uspto-grants-2016_02 |