HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroaniline → 3-(4-Chlorophenyl)-7-(2-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | HCID 11311579 | HCID 11311579 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-(4-Chlorophenyl)-7-(2-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one | HCID 86729809 | 70.5% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(2-methoxyphenyl)thiophene-2-carboxylate (50 mg, 0.21 mmol), triethyl orthoformate (0.41 ml), 4-chloroaniline (45.05 mg, 0.35 mmol), and acetic acid (0.05 ml) were used to give 49.4 mg (0.13 mmol, 70.5% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-c99f16e6396645b5ad271f370cb404b9 |
| Source note | uspto-grants-2016_02 |