反应详情

In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(2-methoxyphenyl)thiophene-2-carboxylate (40 mg, 0.15 mmol), triethyl orthoformate (0.33 ml), p-anisidine (34.8 mg, 0.28 mmol), and acetic acid (0.04 ml) were used to give 31 mg (0.09 mmol, 56.7% yield) of the title compound.