HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroaniline → HCID 78322372, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | HCID 2759760 | HCID 2759760 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 78322372 | HCID 78322372 | 86.9% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(4-methoxyphenyl)thiophene-2-carboxylate (80 mg, 0.3 mmol), triethyl orthoformate (0.66 ml), 4-chloroaniline (71.2 mg, 0.56 mmol), and acetic acid (0.08 ml) were used to give 96.2 mg (0.26 mmol, 86.9% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-af9a57f473f848768c8281d531d1d933 |
| Source note | uspto-grants-2016_02 |