HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroaniline → HCID 78322373, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | HCID 12128604 | HCID 12128604 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 78322373 | HCID 78322373 | 28% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(3,4-dimethoxyphenyl)thiophene-2-carboxylate (80 mg, 0.27 mmol), triethyl orthoformate (0.6 ml), 4-chloroaniline (62.5 mg, 0.51 mmol), and acetic acid (0.09 ml) were used to give 14.5 mg (0.04 mmol, 28% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-e1f66dd5b04d41ae99bc7edec8817242 |
| Source note | uspto-grants-2016_02 |