HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroaniline → HCID 78322374, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | HCID 12128606 | HCID 12128606 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 78322374 | HCID 78322374 | 79.5% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(benzo[d][1,3]dioxol-5-yl)thiophene-2-carboxylate (60 mg, 0.21 mmol), triethyl orthoformate (0.48 ml), 4-chloroaniline (51.0 mg, 0.4 mmol), and acetic acid (0.06 ml) were used to give 47.3 mg (0.17 mmol, 79.5% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-edfcd320fe2d4970948a4c953072f372 |
| Source note | uspto-grants-2016_02 |