HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → HCID 78323004, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Cyclopropanemethanamine | HCID 75646 | — |
| Reactant | Methyl 3-amino-4-phenylthiophene-2-carboxylate | HCID 2759782 | — |
| Reactant | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 78323004 | HCID 78323004 | 62.6% |
Reaction Steps
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (100 mg, 0.43 mmol), triethyl orthoformate (1.0 ml), cyclopropanemethylamine (0.086 ml, 0.99 mmol), and acetic acid (0.1 ml) were used to give 76 mg (0.27 mmol, 62.6% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260448B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-51c71a0859b54eb890c53d78dfcb905e |
| Source note | uspto-grants-2016_02 |